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Tirzepatide

Tirzepatide

02
Metabolic control and weight loss · Dual GLP-1 / GIP agonist
99% Purity Metabolic

Tirzepatide (Mounjaro/Zepbound) is a dual GLP-1/GIP agonist approved by the FDA for type 2 diabetes and obesity. It mimics two gut hormones that regulate appetite, glucose and gastric emptying. In the SURMOUNT trials it produced average weight losses of 20.9% at 72 weeks, making it the current clinical gold standard for the pharmacological treatment of obesity.

Key Benefits
Clinically proven weight loss
Glycemic control superior to semaglutide
Reduction of HbA1c and insulin resistance
Lowering of blood pressure
Reduced cravings and early satiety
Associated cardiovascular protection
Mechanism of Action
A dual agonist that mimics two gut hormones: it activates GLP-1 and GIP receptors to regulate appetite, glucose and gastric emptying. The combined activation of both pathways produces appetite suppression and improved insulin sensitivity superior to those of a single agonist.
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Protocol

Reconstitution & Usage Protocol

Important: Only chill the water 3 minutes before reconstituting the peptide. Do not prepare it with very cold water, as it may freeze, lose efficacy or be damaged.
1Reconstitution
Materials: 1 vial of Tirzepatide 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe · alcohol wipes.
  1. Bring both vials to room temperature for 15–20 minutes.
  2. Disinfect the rubber stoppers with an alcohol wipe and let dry for 30 seconds.
  3. Draw up 2 mL of bacteriostatic water (200 IU in an insulin syringe or 1 fill of a 3 mL syringe).
  4. Inject the water slowly down the inner wall of the vial, never directly onto the powder.
  5. Do not shake. Swirl gently or let stand for 3–5 minutes until the solution is clear.
Label with the date and store in the refrigerator (2–8 °C). Stable for 28–30 days.
2Concentration & Dosing
Reconstituting 10 mg in 2 mL → 5 mg/mL = 50 mcg per IU.
Target doseUnitsVolume
2.5 mg (starting)50 IU0.50 mL
5 mg (maintenance)100 IU1.00 mL
7.5 mg150 IUSplit into 2 doses
10 mg (maximum)200 IUSplit into 2 doses
Universal formula: IU = (dose in mg ÷ 5) × 100
3Application
Route
Subcutaneous in the abdomen, thigh or arm.
Frequency
Once per week, preferably the same day after breakfast.
Cycle
16–24 weeks minimum to see full results.
  • Titration: 2.5 mg weeks 1–4 → 5 mg weeks 5–8 → increase by 2.5 mg every 4 weeks as tolerated.
  • Before applying: let the loaded dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
  • After applying: gentle massage of the area for ~40 seconds to disperse the peptide and improve absorption.
Importante: Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.
1Reconstitución
Materiales: 1 vial de Tirzepatide 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 · toallitas de alcohol.
  1. Atemperar ambos viales a temperatura ambiente 15–20 minutos.
  2. Desinfectar las tapas de goma con toallita de alcohol y dejar secar 30 segundos.
  3. Cargar 2 mL de agua bacteriostática (200 UI en jeringa de insulina o 1 carga de jeringa de 3 mL).
  4. Inyectar el agua lentamente por la pared interior del vial, nunca sobre el polvo directo.
  5. No agitar. Girar suavemente o dejar reposar 3–5 minutos hasta solución transparente.
Etiquetar con fecha y guardar en nevera (2–8 °C). Estable 28–30 días.
2Concentración y dosis
Reconstituyendo 10 mg en 2 mL → 5 mg/mL = 50 mcg por UI.
Dosis objetivoUnidadesVolumen
2,5 mg (inicial)50 UI0,50 mL
5 mg (mantenimiento)100 UI1,00 mL
7,5 mg150 UIDividir en 2 dosis
10 mg (máxima)200 UIDividir en 2 dosis
Fórmula universal: UI = (dosis en mg ÷ 5) × 100
3Aplicación
Vía
Subcutánea en abdomen, muslo o brazo.
Frecuencia
1 vez por semana, mismo día preferiblemente después del desayuno.
Ciclo
16–24 semanas mínimo para ver resultados completos.
  • Titulación: 2,5 mg semanas 1–4 → 5 mg semanas 5–8 → aumentar 2,5 mg cada 4 semanas según tolerancia.
  • Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
  • Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar absorción.
Important : Ne mettre l'eau à refroidir que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car il peut geler, perdre son effet ou être endommagé.
1Reconstitution
Matériel : 1 flacon de Tirzepatide 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 · lingettes alcoolisées.
  1. Ramener les deux flacons à température ambiante pendant 15–20 minutes.
  2. Désinfecter les bouchons en caoutchouc avec une lingette alcoolisée et laisser sécher 30 secondes.
  3. Prélever 2 mL d'eau bactériostatique (200 UI dans une seringue à insuline ou 1 remplissage d'une seringue de 3 mL).
  4. Injecter l'eau lentement le long de la paroi intérieure du flacon, jamais directement sur la poudre.
  5. Ne pas agiter. Faire tourner doucement ou laisser reposer 3–5 minutes jusqu'à obtenir une solution transparente.
Étiqueter avec la date et conserver au réfrigérateur (2–8 °C). Stable 28–30 jours.
2Concentration et dosage
En reconstituant 10 mg dans 2 mL → 5 mg/mL = 50 mcg par UI.
Dose cibleUnitésVolume
2,5 mg (initiale)50 UI0,50 mL
5 mg (entretien)100 UI1,00 mL
7,5 mg150 UIDiviser en 2 doses
10 mg (maximale)200 UIDiviser en 2 doses
Formule universelle : UI = (dose en mg ÷ 5) × 100
3Application
Voie
Sous-cutanée dans l'abdomen, la cuisse ou le bras.
Fréquence
1 fois par semaine, de préférence le même jour après le petit-déjeuner.
Cycle
16–24 semaines minimum pour voir des résultats complets.
  • Titration : 2,5 mg semaines 1–4 → 5 mg semaines 5–8 → augmenter de 2,5 mg toutes les 4 semaines selon la tolérance.
  • Avant l'application : laisser la dose chargée perdre son froid (uniquement la quantité à injecter) — tenir la seringue dans la main 2–3 minutes.
  • Après l'application : massage doux de la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

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Research Highlights

Research Highlights

FAQ

Frequently Asked Questions

How does Tirzepatide differ from a single GLP-1 agonist in research models?

Tirzepatide is a dual agonist that activates both GLP-1 and GIP receptors, whereas a single agonist engages only one pathway. In the SURMOUNT trials this combined activation was associated with average weight reductions of 20.9% at 72 weeks and glycemic control reported as superior to semaglutide.

What concentration results from reconstituting the 10 mg vial?

Reconstituting 10 mg in 2 mL of bacteriostatic water yields 5 mg/mL, equivalent to 50 mcg per IU on a U-100 insulin syringe. As a reference, a 2.5 mg amount corresponds to 50 IU (0.50 mL) and a 5 mg amount to 100 IU (1.00 mL).

How should the reconstituted vial be stored, and for how long?

After reconstitution, label the vial with the date and store it refrigerated at 2–8 °C, where it remains stable for 28–30 days. The water should be chilled only 3 minutes before reconstitution; very cold water may cause the solution to freeze, lose efficacy or be damaged.

What titration schedule is referenced for Tirzepatide?

The referenced schedule administers 2.5 mg during weeks 1–4, then 5 mg during weeks 5–8, increasing by 2.5 mg every 4 weeks as tolerated. Administration is once weekly, subcutaneously in the abdomen, thigh or arm, over a minimum cycle of 16–24 weeks to observe full results.

Related Compounds

Related Compounds

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Retatrutide

Retatrutide (LY3437943) is an experimental peptide developed by Eli Lilly that acts simultaneously on three metabolic receptors: GLP-1, GIP and glucagon. This triple action makes it the most potent agent of its class in obesity clinical trials, with average weight losses exceeding 24% of body weight over 48 weeks. Its mechanism combines appetite suppression (GLP-1), improved insulin sensitivity (GIP) and increased basal energy expenditure (glucagon), producing a synergistic effect on metabolism.

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MOTS-c Metabolic
MOTS-c

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by mitochondrial DNA, not nuclear DNA. It is considered a 'mitochondrial hormone' that regulates energy metabolism, insulin sensitivity and physical endurance. Its levels decline with age and are associated with obesity, type 2 diabetes and loss of muscle function.

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NAD+ Longevity
NAD+

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every cell that takes part in more than 500 metabolic reactions, primarily in energy production (ATP) and DNA repair. Its levels decline drastically with age, and exogenous replenishment is associated with improvements in energy, mitochondrial function, cognitive function and longevity markers. It is one of the pillars of modern anti-aging biohacking.

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