MOTS-c 10 mg | Mitochondrial Metabolic Peptide

MOTS-c

Mitochondrial peptide · Metabolism and physical endurance

99% Purity Metabolic Mitochondrial

MOTS-c (Mitochondrial Open Reading frame of the Twelve S rRNA-c) is a 16-amino-acid peptide encoded by mitochondrial DNA, not nuclear DNA. It is considered a 'mitochondrial hormone' that regulates energy metabolism, insulin sensitivity and physical endurance. Its levels decline with age and are associated with obesity, type 2 diabetes and loss of muscle function.

Key Benefits

Improves insulin sensitivity

Increases physical endurance

Optimizes mitochondrial function

Promotes fat loss

Protects muscle mass

Metabolic anti-aging

Mechanism of Action

As a 'mitochondrial hormone' encoded by mitochondrial DNA, MOTS-c regulates energy metabolism, optimizes mitochondrial function and improves insulin sensitivity and glucose metabolism. This translates into greater physical endurance and aerobic capacity.

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Protocol

Reconstitution & Usage Protocol

Only chill the water for 3 minutes before reconstituting the peptide. Do not prepare it with very cold water, because it may freeze, lose effect or become damaged.

1Reconstitution

1 vial of MOTS-c 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe · alcohol wipes.

Let the vial reach room temperature for 10–15 minutes.
Disinfect the rubber stoppers with an alcohol wipe.
Draw 2 mL of bacteriostatic water (200 UI).
Inject the water slowly down the inner wall of the vial.
Do not shake. Swirl gently until the solution is clear.

Label with the date and refrigerate (2–8 °C). Stable for 28 days.

2Concentration & Dosing

Reconstituting 10 mg in 2 mL → 5 mg/mL = 50 mcg per UI.

Target dose	Units	Volume
0.5 mg (low)	10 UI	0.10 mL
1 mg (standard)	20 UI	0.20 mL
1.5 mg (high)	30 UI	0.30 mL

Universal formula: UI = (dose in mg ÷ 0.05)

3Application

Route

Subcutaneous in the abdomen.

Frequency

2–3 times per week.

Cycle

4–8 weeks. Compatible with intermittent fasting protocols and HIIT training.

Standard protocol: 1 mg, 3 times per week (Monday/Wednesday/Friday).
Before applying: let the drawn dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
After applying: gently massage the area for ~40 seconds to disperse the peptide and improve absorption.

Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.

1Reconstitución

1 vial de MOTS-c 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 · toallitas de alcohol.

Atemperar el vial 10–15 minutos.
Desinfectar las tapas de goma con toallita de alcohol.
Cargar 2 mL de agua bacteriostática (200 UI).
Inyectar el agua lentamente por la pared interior del vial.
No agitar. Girar suavemente hasta solución transparente.

Etiquetar con fecha y refrigerar (2–8 °C). Estable 28 días.

2Concentración y dosis

Reconstituyendo 10 mg en 2 mL → 5 mg/mL = 50 mcg por UI.

Dosis objetivo	Unidades	Volumen
0,5 mg (baja)	10 UI	0,10 mL
1 mg (estándar)	20 UI	0,20 mL
1,5 mg (alta)	30 UI	0,30 mL

Fórmula universal: UI = (dosis en mg ÷ 0,05)

3Aplicación

Vía

Subcutánea en abdomen.

Frecuencia

2–3 veces por semana.

Ciclo

4–8 semanas. Compatible con protocolos de ayuno intermitente y entrenamiento HIIT.

Protocolo estándar: 1 mg, 3 veces por semana (lunes/miércoles/viernes).
Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar absorción.

Ne mettre l'eau à refroidir que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car il peut geler, perdre son effet ou être endommagé.

1Reconstitution

1 flacon de MOTS-c 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 · lingettes alcoolisées.

Laisser le flacon revenir à température ambiante pendant 10–15 minutes.
Désinfecter les bouchons en caoutchouc avec une lingette alcoolisée.
Prélever 2 mL d'eau bactériostatique (200 UI).
Injecter l'eau lentement le long de la paroi intérieure du flacon.
Ne pas agiter. Faire tourner doucement jusqu'à obtenir une solution transparente.

Étiqueter avec la date et réfrigérer (2–8 °C). Stable 28 jours.

2Concentration et dosage

En reconstituant 10 mg dans 2 mL → 5 mg/mL = 50 mcg par UI.

Dose cible	Unités	Volume
0,5 mg (faible)	10 UI	0,10 mL
1 mg (standard)	20 UI	0,20 mL
1,5 mg (élevée)	30 UI	0,30 mL

Formule universelle : UI = (dose en mg ÷ 0,05)

3Application

Voie

Sous-cutanée dans l'abdomen.

Fréquence

2–3 fois par semaine.

Cycle

4–8 semaines. Compatible avec les protocoles de jeûne intermittent et l'entraînement HIIT.

Protocole standard : 1 mg, 3 fois par semaine (lundi/mercredi/vendredi).
Avant l'application : laisser la dose prélevée perdre son froid (uniquement la quantité à injecter) — tenir la seringue dans la main pendant 2–3 minutes.
Après l'application : masser doucement la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

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Research Highlights

MOTS-c is one of the few known peptides encoded directly by mitochondrial DNA, and in research models it translocates to the nucleus under metabolic stress to reprogram gene expression toward adaptive energy metabolism.
Preclinical studies link MOTS-c to improved insulin sensitivity and glucose metabolism, partly via AMPK signaling and enhanced skeletal-muscle glucose uptake in studied tissues.
Because circulating MOTS-c declines with age and is associated with obesity, type 2 diabetes and loss of muscle function, it is investigated as a candidate marker and target in metabolic anti-aging research.

FAQ

Frequently Asked Questions

What makes MOTS-c different from peptides encoded by nuclear DNA?

MOTS-c is one of the few peptides encoded by mitochondrial DNA rather than nuclear DNA. This 16-amino-acid peptide is studied as a 'mitochondrial hormone' that signals to the rest of the cell about energy status, which is the basis for its research interest in metabolism and physical endurance.

Why are MOTS-c levels lower with age?

Research observes that circulating MOTS-c declines with age, a pattern associated with obesity, type 2 diabetes and loss of muscle function. This age-related decline is one reason MOTS-c is studied in the context of metabolic anti-aging.

What working concentration results from reconstituting the 10 mg vial?

Reconstituting 10 mg in 2 mL of bacteriostatic water yields 5 mg/mL, which equals 50 mcg per insulin unit (UI). On this basis a 1 mg dose corresponds to 20 UI (0.20 mL), using the universal formula UI = (dose in mg ÷ 0.05).

Why is MOTS-c described alongside intermittent fasting and HIIT?

Reference protocols describe a 4–8 week cycle compatible with intermittent fasting and HIIT training, because MOTS-c is studied as an exercise-mimetic peptide that engages the same metabolic adaptations as physical training. This makes it of research interest where mitochondrial function and aerobic capacity are the focus.

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