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Tesamorelin

Tesamorelin

12
Potent GHRH analog · Visceral fat reduction
99% Purity Growth Hormone Clinically Approved

Tesamorelin is a synthetic GHRH analog approved by the FDA for the treatment of HIV-associated lipodystrophy, known for its efficacy in reducing abdominal visceral fat. It stimulates the pituitary to release GH in a pulsatile manner, with potency superior to CJC-1295. It is the only secretagogue with robust clinical evidence for visceral fat reduction and improvement of hepatic markers in non-alcoholic fatty liver disease.

Key Benefits
Reduces abdominal visceral fat
Improves non-alcoholic fatty liver
Potently raises GH and IGF-1
Improves lipid profile
Boosts cognitive function
Preserves lean mass
Mechanism of Action
As a synthetic GHRH analog, it stimulates the pituitary to release growth hormone in a pulsatile manner, with potency superior to CJC-1295. The resulting rise in GH and IGF-1 activates selective visceral lipolysis and improves hepatic markers.
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Protocol

Reconstitution & Usage Protocol

Important: Only chill the water for 3 minutes before reconstituting the peptide. Do not prepare it with very cold water, because it can freeze, lose its effect, or be damaged.
1Reconstitution
Materials: 1 vial of Tesamorelin 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe · alcohol wipes.
  1. Bring the vial to room temperature for 10–15 minutes.
  2. Disinfect the rubber caps with an alcohol wipe.
  3. Draw up 2 mL of bacteriostatic water (200 IU).
  4. Inject the water slowly down the inner wall of the vial.
  5. Do not shake. Swirl gently until the solution is clear.
Label with the date and refrigerate (2–8 °C). Stable for 28 days.
2Concentration & Dosing
Reconstituting 10 mg in 2 mL → 5 mg/mL = 50 mcg per IU.
Target doseUnitsVolume
1 mg (low)20 IU0.20 mL
2 mg (FDA standard)40 IU0.40 mL
2 mg (advanced)40 IU0.40 mL
Universal formula: IU = (dose in mg ÷ 5) × 100
3Application
Route
Subcutaneous in the abdomen.
Frequency
Once a day, preferably before sleep.
Cycle
12–24 weeks to see significant visceral reduction (FDA protocol).
  • Do NOT stack with CJC-1295 or Sermorelin — competition for the same receptors (redundant).
  • Before applying: let the loaded dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
  • After applying: gently massage the area for ~40 seconds to disperse the peptide and improve absorption.
Importante: Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.
1Reconstitución
Materiales: 1 vial de Tesamorelin 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 · toallitas de alcohol.
  1. Atemperar el vial 10–15 minutos.
  2. Desinfectar las tapas de goma con toallita de alcohol.
  3. Cargar 2 mL de agua bacteriostática (200 UI).
  4. Inyectar el agua lentamente por la pared interior del vial.
  5. No agitar. Girar suavemente hasta solución transparente.
Etiquetar con fecha y refrigerar (2–8 °C). Estable 28 días.
2Concentración y dosis
Reconstituyendo 10 mg en 2 mL → 5 mg/mL = 50 mcg por UI.
Dosis objetivoUnidadesVolumen
1 mg (baja)20 UI0,20 mL
2 mg (estándar FDA)40 UI0,40 mL
2 mg (avanzada)40 UI0,40 mL
Fórmula universal: UI = (dosis en mg ÷ 5) × 100
3Aplicación
Vía
Subcutánea en abdomen.
Frecuencia
1 vez al día, preferiblemente antes de dormir.
Ciclo
12–24 semanas para ver reducción visceral significativa (protocolo FDA).
  • NO stackear con CJC-1295 o Sermorelin — competencia por mismos receptores (redundante).
  • Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
  • Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar absorción.
Important : Ne mettre l'eau à refroidir que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car il peut geler, perdre son effet ou être endommagé.
1Reconstitution
Matériel : 1 flacon de Tesamorelin 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 · lingettes alcoolisées.
  1. Laisser le flacon revenir à température ambiante pendant 10 à 15 minutes.
  2. Désinfecter les bouchons en caoutchouc avec une lingette alcoolisée.
  3. Prélever 2 mL d'eau bactériostatique (200 UI).
  4. Injecter l'eau lentement le long de la paroi intérieure du flacon.
  5. Ne pas agiter. Faire tourner doucement jusqu'à obtenir une solution transparente.
Étiqueter avec la date et réfrigérer (2–8 °C). Stable 28 jours.
2Concentration et dosage
En reconstituant 10 mg dans 2 mL → 5 mg/mL = 50 mcg par UI.
Dose cibleUnitésVolume
1 mg (faible)20 UI0,20 mL
2 mg (standard FDA)40 UI0,40 mL
2 mg (avancée)40 UI0,40 mL
Formule universelle : UI = (dose en mg ÷ 5) × 100
3Application
Voie
Sous-cutanée dans l'abdomen.
Fréquence
1 fois par jour, de préférence avant le coucher.
Cycle
12 à 24 semaines pour observer une réduction viscérale significative (protocole FDA).
  • NE PAS associer au CJC-1295 ou au Sermorelin — concurrence pour les mêmes récepteurs (redondant).
  • Avant l'application : laisser la dose prélevée perdre son froid (seulement la quantité à injecter) — tenir la seringue dans la main 2 à 3 minutes.
  • Après l'application : masser doucement la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

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Research Highlights

Research Highlights

FAQ

Frequently Asked Questions

What is Tesamorelin and how does it work in research models?

Tesamorelin is a synthetic GHRH analog studied for its ability to stimulate the pituitary to release growth hormone in a pulsatile pattern, with potency reported as superior to CJC-1295. In research models, the resulting GH and IGF-1 rise drives selective abdominal visceral fat reduction. It is supplied strictly for laboratory research use only.

How is the 10 mg vial reconstituted and dosed in units?

Reconstituting 10 mg in 2 mL of bacteriostatic water (200 IU) yields 5 mg/mL, equal to 50 mcg per IU. A 1 mg draw is 20 IU (0.20 mL) and the 2 mg FDA-standard draw is 40 IU (0.40 mL). The universal formula is IU = (dose in mg ÷ 5) × 100.

How does Tesamorelin differ from CJC-1295 or Sermorelin?

Tesamorelin is reported as more potent than CJC-1295 and is the only secretagogue with robust clinical evidence specifically for visceral fat reduction and improved hepatic markers in non-alcoholic fatty liver disease. Because it acts on the same GHRH receptors, it should not be stacked with CJC-1295 or Sermorelin, as the combination is redundant.

How should Tesamorelin be stored after reconstitution?

After reconstitution, label the vial with the date and refrigerate it at 2–8 °C, where it remains stable for 28 days. The bacteriostatic water should only be chilled for 3 minutes before reconstitution, never used very cold, to avoid freezing or degrading the peptide.

Related Compounds

Related Compounds

Ipamorelin Growth Hormone
Ipamorelin

Ipamorelin is a GH secretagogue pentapeptide considered the most selective and 'cleanest' of its class. Unlike GHRP-6 or GHRP-2, it does not cause a notable rise in cortisol, prolactin or appetite, making it the preferred option for anti-aging, fat-loss and recovery protocols without hormonal side effects. It generates a physiological GH pulse similar to the natural one, ideal for prolonged use.

99% Purity
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CJC-1295 No DAC Growth Hormone
CJC-1295 No DAC

CJC-1295 No DAC (without Drug Affinity Complex), also called Modified GRF 1-29, is a synthetic analog of growth hormone-releasing hormone (GHRH) with a short half-life (~30 minutes). This generates a physiological GH pulse similar to the natural one, without sustained elevations that could desensitize the pituitary. It is almost always combined with a GHRP (Ipamorelin or GHRP-6) for a synergistic effect 5–10 times greater than either one alone.

99% Purity
Details →
IGF-1 LR3 Growth
IGF-1 LR3

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a modified version of natural IGF-1 with an extended half-life of ~20–30 hours (vs. 15 minutes for native IGF-1). It acts directly on IGF-1 receptors to stimulate protein synthesis, muscle hyperplasia (the creation of new muscle cells), and tissue recovery. It is one of the most potent compounds for lean-mass gain and repair in the performance world.

99% Purity
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