Epithalon 10 mg — Telomerase-Activating Longevity Peptide

Epithalon

Longevity peptide · Telomerase activator

99% Purity Longevity Telomere

Epithalon (Epitalon) is a synthetic tetrapeptide developed in Russia from studies with pineal-gland extracts. Its main mechanism is the activation of the enzyme telomerase, which lengthens the telomeres (the protective ends of the chromosomes) and delays cellular senescence. Long-term studies in elderly subjects have shown reduced mortality and improvements in aging biomarkers.

Key Benefits

Activates telomerase and lengthens telomeres

Improves melatonin production

Optimizes sleep and circadian rhythm

Reduces markers of aging

Supports the immune system

Cellular antioxidant protection

Mechanism of Action

It activates the enzyme telomerase, which lengthens the telomeres —the protective ends of the chromosomes— and delays cellular senescence. It also modulates the pineal neuroendocrine axis, restoring natural melatonin production and circadian rhythms.

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Protocol

Reconstitution & Usage Protocol

Important: Only chill the water for 3 minutes before reconstituting the peptide. Do not prepare it with very cold water, because it may freeze, lose effect or be damaged.

1Reconstitution

Materials: 1 vial of Epithalon 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe · alcohol wipes.

Bring the vial to room temperature for 10–15 minutes.
Disinfect the rubber stoppers with an alcohol wipe.
Draw up 2 mL of bacteriostatic water (200 IU).
Inject the water slowly down the inner wall of the vial.
Do not shake. Swirl gently until the solution is clear.

Label with the date and refrigerate (2–8 °C). Stable for 28 days.

2Concentration & Dosing

Reconstituting 10 mg in 2 mL → 5 mg/mL = 50 mcg per IU.

Target dose	Units	Volume
5 mg (low)	100 IU	1.00 mL
10 mg (standard)	200 IU	Split into 2 doses
Monthly load 50 mg	10 days × 100 IU	1.00 mL/day

Universal formula: IU = (dose in mg ÷ 5) × 100

3Application

Route

Subcutaneous in the abdomen.

Frequency

Ideal time: at night, before sleep, to synchronize with pineal production.

Cycle

Classic protocol: 5–10 mg/day for 10–20 consecutive days, 1–2 times per year. Alternative protocol: 100 mcg–1 mg/day continuously for 1–3 months.

Before applying: let the loaded dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
After applying: gently massage the area for ~40 seconds to disperse the peptide and improve absorption.

Importante: Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.

1Reconstitución

Materiales: 1 vial de Epithalon 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 · toallitas de alcohol.

Atemperar el vial 10–15 minutos.
Desinfectar las tapas de goma con toallita de alcohol.
Cargar 2 mL de agua bacteriostática (200 UI).
Inyectar el agua lentamente por la pared interior del vial.
No agitar. Girar suavemente hasta solución transparente.

Etiquetar con fecha y refrigerar (2–8 °C). Estable 28 días.

2Concentración y dosis

Reconstituyendo 10 mg en 2 mL → 5 mg/mL = 50 mcg por UI.

Dosis objetivo	Unidades	Volumen
5 mg (baja)	100 UI	1,00 mL
10 mg (estándar)	200 UI	Dividir en 2 dosis
Carga mensual 50 mg	10 días × 100 UI	1,00 mL/día

Fórmula universal: UI = (dosis en mg ÷ 5) × 100

3Aplicación

Vía

Subcutánea en abdomen.

Frecuencia

Hora ideal: noche, antes de dormir, para sincronizar con la producción pineal.

Ciclo

Protocolo clásico: 5–10 mg/día durante 10–20 días consecutivos, 1–2 veces al año. Protocolo alternativo: 100 mcg–1 mg/día continuo por 1–3 meses.

Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar la absorción.

Important : Ne mettre l'eau à refroidir que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car il peut geler, perdre son effet ou être endommagé.

1Reconstitution

Matériel : 1 flacon d'Epithalon 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 · lingettes alcoolisées.

Laisser le flacon revenir à température ambiante pendant 10–15 minutes.
Désinfecter les bouchons en caoutchouc avec une lingette alcoolisée.
Prélever 2 mL d'eau bactériostatique (200 UI).
Injecter l'eau lentement le long de la paroi interne du flacon.
Ne pas secouer. Faire tourner doucement jusqu'à obtenir une solution transparente.

Étiqueter avec la date et réfrigérer (2–8 °C). Stable 28 jours.

2Concentration et dosage

En reconstituant 10 mg dans 2 mL → 5 mg/mL = 50 mcg par UI.

Dose cible	Unités	Volume
5 mg (basse)	100 UI	1,00 mL
10 mg (standard)	200 UI	Diviser en 2 doses
Charge mensuelle 50 mg	10 jours × 100 UI	1,00 mL/jour

Formule universelle : UI = (dose en mg ÷ 5) × 100

3Application

Voie

Sous-cutanée dans l'abdomen.

Fréquence

Heure idéale : le soir, avant de dormir, pour se synchroniser avec la production pinéale.

Cycle

Protocole classique : 5–10 mg/jour pendant 10–20 jours consécutifs, 1–2 fois par an. Protocole alternatif : 100 mcg–1 mg/jour en continu pendant 1–3 mois.

Avant l'application : laisser la dose prélevée perdre son froid (uniquement la quantité à injecter) — tenir la seringue dans la main pendant 2–3 minutes.
Après l'application : masser doucement la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

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Research Highlights

Long-term research in elderly subjects reported reduced mortality and improvements in aging biomarkers among groups receiving the pineal tetrapeptide.
Cell-culture study models associate Epithalon with activation of telomerase and measurable lengthening of telomeres, correlating with delayed replicative senescence.
Research data describe restored melatonin secretion and normalized circadian rhythms, which investigators link to its modulation of the pineal neuroendocrine axis.

FAQ

Frequently Asked Questions

What is Epithalon and how does it act on telomeres in research models?

Epithalon (Epitalon) is a synthetic tetrapeptide derived from pineal-gland extract research. In study models it activates the enzyme telomerase, which lengthens the telomeres—the protective ends of the chromosomes—and is associated with delayed cellular senescence. It is supplied strictly for in-vitro and laboratory research use.

Why is Epithalon linked to melatonin and sleep in the literature?

Because it originates from pineal-gland research, Epithalon is reported to modulate the pineal neuroendocrine axis and restore natural melatonin production. Study data associate this with improved sleep quality and re-synchronized circadian rhythms, which is why protocols favor evening timing. These observations describe research findings only and are not human-use claims.

What administration schedule appears in Epithalon research protocols?

Two patterns dominate the literature. A classic protocol uses 5–10 mg/day for 10–20 consecutive days, 1–2 times per year; an alternative uses 100 mcg–1 mg/day continuously for 1–3 months. The subcutaneous route in the abdomen is standard in study design. These figures describe the literature and are not dosing instructions for humans.

How is Epithalon reconstituted and stored for the lab?

Add 2 mL of bacteriostatic water (200 IU) down the inner wall of the 10 mg vial, yielding 5 mg/mL or 50 mcg per IU, and swirl gently without shaking. Chill the water only 3 minutes beforehand—never use very cold water. Label with the date and refrigerate at 2–8 °C, where it stays stable for 28 days.

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