Semax 10 mg — Nootropic, BDNF & Neuroprotection

Protocol

Reconstitution & Usage Protocol

Important: Only start cooling the water 3 minutes before reconstituting the peptide. Do not prepare with very cold water, because it can freeze, lose effect or be damaged.

1Reconstitution

Materials: 1 vial of Semax 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe or nasal spray bottle · alcohol wipes.

Let the vial come to room temperature for 10–15 minutes.
Disinfect the rubber cap with an alcohol wipe.
Draw up 2 mL of bacteriostatic water (200 IU) or transfer to a sterilized nasal spray bottle.
Inject the water slowly down the inner wall of the vial.
Do not shake. Swirl gently until the solution is clear.

Label with the date and refrigerate (2–8 °C). Stable for 28 days.

2Concentration & Dosing

Reconstituting 10 mg in 2 mL → 5 mg/mL = 50 mcg per IU.

Target dose	Units	Volume
500 mcg (low)	10 IU / 1 puff	0.10 mL
750 mcg (standard)	15 IU / 2 puffs	0.15 mL
1 mg (high)	20 IU / 3 puffs	0.20 mL

Universal formula: IU = (dose in mcg ÷ 50)

3Application

Route

Intranasal (preferred to reach the CNS directly).

Frequency

1–3 times a day, preferably in the morning and midday (it can be stimulating). Standard dose: 600–900 mcg/day in divided amounts.

Cycle

2–4 consecutive weeks, with breaks. Compatible with Selank for a focus/calm balance.

Before applying: let the drawn-up dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
After applying: gently massage the area for ~40 seconds to disperse the peptide and improve absorption.

Importante: Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.

1Reconstitución

Materiales: 1 vial de Semax 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 o botella spray nasal · toallitas de alcohol.

Atemperar el vial 10–15 minutos.
Desinfectar la tapa de goma con toallita de alcohol.
Cargar 2 mL de agua bacteriostática (200 UI) o transferir a botella spray nasal esterilizada.
Inyectar el agua lentamente por la pared interior del vial.
No agitar. Girar suavemente hasta solución transparente.

Etiquetar con fecha y refrigerar (2–8 °C). Estable 28 días.

2Concentración y dosis

Reconstituyendo 10 mg en 2 mL → 5 mg/mL = 50 mcg por UI.

Dosis objetivo	Unidades	Volumen
500 mcg (baja)	10 UI / 1 puff	0,10 mL
750 mcg (estándar)	15 UI / 2 puffs	0,15 mL
1 mg (alta)	20 UI / 3 puffs	0,20 mL

Fórmula universal: UI = (dosis en mcg ÷ 50)

3Aplicación

Vía

Intranasal (preferida para llegar directo al SNC).

Frecuencia

1–3 veces al día, preferiblemente en la mañana y mediodía (puede ser estimulante). Dosis estándar: 600–900 mcg/día repartidos.

Ciclo

2–4 semanas seguidas, con descansos. Compatible con Selank para balance foco/calma.

Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar absorción.

Important : Ne mettre l'eau à refroidir que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car elle peut geler, perdre son effet ou s'abîmer.

1Reconstitution

Matériel : 1 flacon de Semax 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 ou flacon spray nasal · lingettes alcoolisées.

Laisser le flacon revenir à température ambiante pendant 10–15 minutes.
Désinfecter le bouchon en caoutchouc avec une lingette alcoolisée.
Prélever 2 mL d'eau bactériostatique (200 UI) ou transférer dans un flacon spray nasal stérilisé.
Injecter l'eau lentement le long de la paroi intérieure du flacon.
Ne pas secouer. Faire tourner doucement jusqu'à obtenir une solution transparente.

Étiqueter avec la date et réfrigérer (2–8 °C). Stable 28 jours.

2Concentration et dosage

En reconstituant 10 mg dans 2 mL → 5 mg/mL = 50 mcg par UI.

Dose cible	Unités	Volume
500 mcg (faible)	10 UI / 1 puff	0,10 mL
750 mcg (standard)	15 UI / 2 puffs	0,15 mL
1 mg (élevée)	20 UI / 3 puffs	0,20 mL

Formule universelle : UI = (dose en mcg ÷ 50)

3Application

Voie

Intranasale (préférée pour atteindre directement le SNC).

Fréquence

1–3 fois par jour, de préférence le matin et à midi (peut être stimulant). Dose standard : 600–900 mcg/jour répartis.

Cycle

2–4 semaines consécutives, avec des pauses. Compatible avec le Selank pour un équilibre concentration/calme.

Avant l'application : laisser la dose prélevée perdre son froid (seulement la quantité à injecter) — tenir la seringue dans la main pendant 2–3 minutes.
Après l'application : masser doucement la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

Open dosage calculator →

Research Highlights

As an ACTH (4-10) analog, Semax is studied for elevating BDNF and NGF expression without the hormonal activity associated with full-length ACTH.
Developed in Russia and approved there for strokes and cognitive disorders, Semax is investigated in research models for focus, working memory and mental processing speed.
Its neuroprotective profile is explored in laboratory studies of resilience against oxidative stress and age-related cognitive decline.

FAQ

Frequently Asked Questions

What is Semax and what is it studied for?

Semax is a synthetic heptapeptide derived from the ACTH (4-10) hormone, supplied strictly for laboratory research. It is investigated in research models for elevating BDNF and NGF, modulating dopamine and serotonin, improving neuroplasticity, focus and neuroprotection, and is not intended for human or veterinary use.

How is the 10 mg Semax vial reconstituted for research?

Add 2 mL of bacteriostatic water (200 IU) down the inner wall of the 10 mg vial, yielding 5 mg/mL = 50 mcg per IU. Cool the water only 3 minutes beforehand, do not shake, and swirl gently until clear, then label with the date and refrigerate at 2–8 °C, where it stays stable for 28 days.

What routes and doses are referenced in Semax research?

Research protocols reference the intranasal route, preferred to reach the CNS directly, applied 1–3 times a day. The standard reference dose is 600–900 mcg/day in divided amounts, with single research draws of 500 mcg (10 IU), 750 mcg (15 IU) or 1 mg (20 IU). These parameters are laboratory reference only and are not dosing guidance for living subjects.

What cycle length and combinations are referenced for Semax?

Research reference cycles run 2–4 consecutive weeks followed by breaks. Because Semax can be stimulating, application is preferably in the morning and midday, and it is documented as compatible with Selank for a focus/calm balance in research models.

Related Compounds

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