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Kisspeptin-10

Kisspeptin-10

18
HPG axis activator · Fertility and endogenous testosterone
99% Purity Hormonal Fertility

Kisspeptin-10 is a decapeptide discovered in 1996 that acts as the 'master regulator' of the hypothalamic-pituitary-gonadal (HPG) axis. It stimulates the release of GnRH, which in turn activates LH and FSH, triggering endogenous testosterone production in men and estrogen production in women. It is an emerging tool for infertility, functional hypogonadism, libido, and post-steroid-cycle recovery.

Key Benefits
Increases endogenous testosterone
Improves libido and sexual function
Stimulates fertility in both sexes
Natural alternative to HCG in PCT
Activates the complete HPG axis
Does not suppress natural production
Mechanism of Action
It acts as the 'master regulator' of the hypothalamic-pituitary-gonadal (HPG) axis, stimulating the release of GnRH, which in turn activates LH and FSH. This triggers endogenous testosterone production in men and estrogen production in women.
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Protocol

Reconstitution & Usage Protocol

Important: Only chill the water 3 minutes before reconstituting the peptide. Do not prepare with very cold water, because it can freeze, lose effectiveness, or be damaged.
1Reconstitution
Materials: 1 vial of Kisspeptin-10 10 mg · 1 vial of bacteriostatic water · U-100 insulin syringe · 3 mL syringe · alcohol wipes.
  1. Bring the vial to room temperature for 10–15 minutes.
  2. Disinfect the rubber caps with an alcohol wipe.
  3. Draw 3 mL of bacteriostatic water with the 3 mL syringe.
  4. Inject the water slowly down the inner wall of the vial.
  5. Do not shake. Swirl gently until the solution is clear.
Label with the date and refrigerate (2–8 °C). Stable for 28 days.
2Concentration & Dosing
Reconstituting 10 mg in 3 mL → 3.33 mg/mL ≈ 33.3 mcg per UI.
Target doseUnitsVolume
333 mcg (low)10 UI0.10 mL
500 mcg (standard)15 UI0.15 mL
1 mg (high)30 UI0.30 mL
Universal formula: UI = (dose in mcg ÷ 33.3)
3Application
Route
Subcutaneous in the abdomen.
Frequency
Once a day or every other day.
Cycle
Standard protocol: 500 mcg daily for 4–8 weeks. PCT: alternative to HCG, combinable with Enclomiphene or Clomid.
  • Before applying: let the drawn dose lose its chill (only the amount to be injected) — hold the syringe in your hand for 2–3 minutes.
  • After applying: gentle massage of the area for ~40 seconds to disperse the peptide and improve absorption.
Importante: Solo poner a enfriar el agua 3 minutos antes de reconstituir el péptido. No preparar con agua muy fría, porque se puede congelar, perder efecto o dañarse.
1Reconstitución
Materiales: 1 vial de Kisspeptin-10 10 mg · 1 vial de agua bacteriostática · jeringa de insulina U-100 · jeringa de 3 mL · toallitas de alcohol.
  1. Atemperar el vial 10–15 minutos.
  2. Desinfectar las tapas de goma con toallita de alcohol.
  3. Cargar 3 mL de agua bacteriostática con jeringa de 3 mL.
  4. Inyectar el agua lentamente por la pared interior del vial.
  5. No agitar. Girar suavemente hasta solución transparente.
Etiquetar con fecha y refrigerar (2–8 °C). Estable 28 días.
2Concentración y dosis
Reconstituyendo 10 mg en 3 mL → 3,33 mg/mL ≈ 33,3 mcg por UI.
Dosis objetivoUnidadesVolumen
333 mcg (baja)10 UI0,10 mL
500 mcg (estándar)15 UI0,15 mL
1 mg (alta)30 UI0,30 mL
Fórmula universal: UI = (dosis en mcg ÷ 33,3)
3Aplicación
Vía
Subcutánea en abdomen.
Frecuencia
1 vez al día o día por medio.
Ciclo
Protocolo estándar: 500 mcg diarios durante 4–8 semanas. PCT: alternativa a HCG combinable con Enclomifeno o Clomid.
  • Antes de aplicar: dejar que la dosis cargada pierda el frío (solo la cantidad a inyectar) — sostener la jeringa en la mano 2–3 minutos.
  • Después de aplicar: masaje suave en la zona durante ~40 segundos para dispersar el péptido y mejorar absorción.
Important : Ne refroidir l'eau que 3 minutes avant de reconstituer le peptide. Ne pas préparer avec de l'eau très froide, car elle peut geler, perdre son effet ou être endommagée.
1Reconstitution
Matériel : 1 flacon de Kisspeptin-10 10 mg · 1 flacon d'eau bactériostatique · seringue à insuline U-100 · seringue de 3 mL · lingettes alcoolisées.
  1. Laisser le flacon revenir à température ambiante pendant 10–15 minutes.
  2. Désinfecter les bouchons en caoutchouc avec une lingette alcoolisée.
  3. Prélever 3 mL d'eau bactériostatique avec la seringue de 3 mL.
  4. Injecter l'eau lentement le long de la paroi interne du flacon.
  5. Ne pas agiter. Faire tourner doucement jusqu'à obtenir une solution transparente.
Étiqueter avec la date et réfrigérer (2–8 °C). Stable 28 jours.
2Concentration et dosage
En reconstituant 10 mg dans 3 mL → 3,33 mg/mL ≈ 33,3 mcg par UI.
Dose cibleUnitésVolume
333 mcg (faible)10 UI0,10 mL
500 mcg (standard)15 UI0,15 mL
1 mg (élevée)30 UI0,30 mL
Formule universelle : UI = (dose en mcg ÷ 33,3)
3Application
Voie
Sous-cutanée dans l'abdomen.
Fréquence
1 fois par jour ou un jour sur deux.
Cycle
Protocole standard : 500 mcg par jour pendant 4–8 semaines. PCT : alternative à l'HCG, combinable avec l'Enclomifène ou le Clomid.
  • Avant l'application : laisser la dose prélevée perdre son froid (uniquement la quantité à injecter) — tenir la seringue dans la main pendant 2–3 minutes.
  • Après l'application : massage doux de la zone pendant ~40 secondes pour disperser le peptide et améliorer l'absorption.

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Research Highlights

Research Highlights

FAQ

Frequently Asked Questions

What does Kisspeptin-10 do to the HPG axis in research?

In research models, Kisspeptin-10 acts as the master regulator of the hypothalamic-pituitary-gonadal axis: it stimulates GnRH release, which activates LH and FSH and triggers endogenous testosterone in men and estrogen in women.

How is Kisspeptin-10 reconstituted for research?

The 10 mg vial is reconstituted with 3 mL of bacteriostatic water, giving 3.33 mg/mL (≈ 33.3 mcg per UI). The water should be chilled only 3 minutes beforehand; injecting it down the inner wall and swirling gently keeps the solution clear.

What is the standard research protocol for Kisspeptin-10?

The standard reference protocol is 500 mcg daily (15 UI / 0.15 mL) administered subcutaneously in the abdomen for 4–8 weeks, dosed once a day or every other day.

How does Kisspeptin-10 compare to HCG in PCT research?

Kisspeptin-10 is studied as a modern alternative to HCG for post-cycle recovery: it activates the full HPG axis upstream rather than directly stimulating the testes, and it can be combined with Enclomiphene or Clomid in research protocols.

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