Description

PROPIONATE 100 (Testosterone Propionate) is a fast-acting esterified form of testosterone used primarily in males to address androgen deficiency states such as hypogonadism, delayed puberty, and growth disorders. It is particularly indicated in patients with genetic abnormalities, hypothalamic-pituitary dysfunction, or in individuals recovering from gonadotoxic treatments like chemotherapy. PROPIONATE 100 may also be utilized as part of adjuvant therapy in women with metastatic breast carcinoma. This preparation is supplied as an injectable solution delivering 100mg of testosterone propionate per milliliter, along with pharmaceutically acceptable excipients.

Metabolic Interactions

Following intramuscular injection, testosterone propionate is hydrolyzed to release free testosterone, which binds to intracellular androgen receptors. This receptor-ligand interaction modulates gene expression to promote the development of male primary and secondary sexual characteristics, as well as maintain spermatogenesis. Testosterone propionate possesses potent androgenic and moderate anabolic activity, promoting muscle protein synthesis, nitrogen retention, erythropoiesis, and bone density improvements. Due to its short ester chain, it has a rapid onset and relatively brief duration of action, necessitating frequent administration. Beyond its clinical applications, it is commonly employed in performance enhancement and physique optimization contexts.

Dosage

The recommended dosing protocol involves intramuscular injections of 100mg every two to three days, tailored to individual therapeutic needs and serum testosterone monitoring.

Drug Interactions

Prior to initiating PROPIONATE 100, patients must inform their healthcare provider of any concomitant use of:

• Antidiabetic agents (testosterone may alter glycemic control)

• Warfarin (risk of enhanced anticoagulant response)

• Propranolol (possible metabolic interference)

• Systemic corticosteroids (increased risk of fluid retention)

• Oxyphenbutazone (potential displacement from binding proteins)