ENANTHATE 250

Description

ENANTHATE 250 (Testosterone Enanthate) is an esterified derivative of endogenous testosterone utilized in androgen replacement protocols for male patients with clinically diagnosed hypogonadism. It is indicated in conditions such as delayed sexual maturation, growth deficiencies linked to androgen insufficiency, and testicular dysfunction resulting from genetic anomalies, hypothalamic-pituitary axis disruption, or cytotoxic treatments like chemotherapy. Additionally, testosterone enanthate is employed as an adjuvant therapy in women diagnosed with specific forms of advanced-stage breast cancer. This formulation is delivered intramuscularly, containing 250mg of testosterone enanthate per milliliter, suspended in a sterile oil vehicle with pharmaceutical-grade excipients.

Metabolic Interactions

Testosterone enanthate acts as a slow-release prodrug of testosterone. Upon intramuscular administration, it undergoes enzymatic cleavage, releasing free testosterone which binds to intracellular androgen receptors. This binding initiates transcriptional activation of androgen-responsive genes involved in the development of male reproductive structures, spermatogenesis, and secondary sexual traits. The compound exhibits robust androgenic activity and moderate anabolic effects, including facilitation of muscle protein synthesis, enhanced nitrogen retention, increased bone mineral density, and skeletal maturation.

Dosage

The typical dosing regimen involves 250mg administered via deep intramuscular injection every 1 to 4 weeks, adjusted according to patient response and serum testosterone levels.

Drug Interactions

Patients should notify their healthcare provider if they are using any of the following agents prior to starting ENANTHATE 250, due to potential pharmacodynamic or pharmacokinetic interactions:

Hypoglycemic agents (may necessitate dosage adjustment)
Warfarin (may enhance anticoagulant activity)
Beta-blockers such as propranolol (metabolic interference possible)
Systemic corticosteroids (risk of fluid retention and electrolyte imbalance)
Oxyphenbutazone (may compete for protein-binding sites)

Side Effects

Adverse reactions observed with testosterone enanthate administration may include:

Virilization symptoms
Deepening of the voice
Alterations in sexual drive
Acneiform eruptions
Gynecomastia
Allergic manifestations
Hypertension and other cardiovascular risks
Thrombotic events
Mood swings or emotional instability
Hepatic strain or dysfunction
Insomnia or disrupted sleep cycles
Peripheral edema
Risk of cerebrovascular accidents

Composition

Testosterone Enanthate .......................... 250mg
Excipients ................................................... q.s