CYPIONATE 250

CYPIONATE 250

Description

CYPIONATE 250 (Testosterone Cypionate) is a long-acting injectable androgen used in androgen replacement therapy for males presenting with testosterone deficiency syndromes. Indications include conditions such as delayed puberty, androgen insufficiency due to hypothalamic or pituitary dysfunction, and gonadal failure secondary to genetic disorders or cytotoxic therapies such as chemotherapy. In female patients, CYPIONATE 250 may be used as palliative treatment in selected cases of hormone-responsive metastatic breast carcinoma. Each milliliter of this intramuscular preparation delivers 250mg of testosterone cypionate in an oil-based solution, stabilized with pharmaceutical excipients.

Metabolic Interactions

As a depot prodrug, testosterone cypionate is enzymatically cleaved to release free testosterone following intramuscular administration. This active androgen binds to intracellular androgen receptors, modulating gene expression that governs male sexual differentiation, spermatogenesis, and the development of secondary sex characteristics. The compound exhibits pronounced androgenic activity alongside moderate anabolic potency, promoting protein synthesis, muscle hypertrophy, erythropoiesis, and increased bone mineral density.

Dosage

The typical clinical regimen involves intramuscular administration of 250mg every 1 to 4 weeks, depending on individual hormonal response and serum testosterone monitoring.

Drug Interactions

Before initiating CYPIONATE 250, patients should consult with a healthcare provider if concurrently using:
  • Antidiabetic agents (due to potential changes in insulin sensitivity)
  • Warfarin (risk of potentiated anticoagulant effects)
  • Beta-blockers such as propranolol (may alter pharmacodynamics)
  • Systemic corticosteroids (potential for additive fluid retention)
  • Oxyphenbutazone (competition for plasma protein-binding sites)

Side Effects

Adverse effects potentially associated with testosterone cypionate include:
  • Signs of virilization 
  • Deepening of the voice 
  • Libido fluctuations 
  • Acneiform eruptions 
  • Gynecomastia 
  • Allergic or hypersensitivity reactions 
  • Hypertension and cardiovascular complications 
  • Thrombotic events 
  • Emotional lability or mood disorders 
  • Hepatic enzyme elevation or hepatotoxicity 
  • Insomnia or disrupted circadian rhythm 
  • Peripheral edema 
  • Increased risk of stroke 

Composition

  • Testosterone Cypionate ......................... 250mg
Excipients ................................................... q.s

Precautions for Storage

Due to the high concentration of active ingredient, CYPIONATE 250 may crystallize when stored at low temperatures. This physical change does not compromise the product’s pharmacological activity, safety, or efficacy. If crystallization occurs, warming the vial and gently agitating it allows the solution to re-dissolve appropriately. Always store according to manufacturer guidelines to preserve integrity.

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